The inhibitory concentrations causing a 50% reduction in tumor-cell proliferation (IC50) are between 1.2 to 4.5 mM. Service & Support. Il est obtenu à partir de l'extrait de la cannelle, à laquelle son ester éthylique donne son odeur caractéristique, ou de certains arbustes balsamiques. Fabrication de produits organiques Hygiène et sécurité Apparence . One such malignancy that still remains a therapeutic challenge mainly due to its heterogeneity and inaccessibility to t … Solide cristallin, jaunâtre à odeur aromatique. Cinnamic acid; Utilisation et sources d'émission. trans-cinnamic acid: ChEBI ID CHEBI:35697: ChEBI ASCII Name trans-cinnamic acid: Definition The E (trans) isomer of cinnamic acid: Stars This entity has been manually annotated by the ChEBI Team. Cinnamic acid, Pharmaceutical Secondary Standard; Certified Reference Material, certified reference material, pharmaceutical secondary standard, pkg of 200 mg, 1133933: Cinnamic acid, United States Pharmacopeia (USP) Reference Standard, 8.00235: Cinnamic acid, for synthesis, Sorry we cannot compare more than 4 products at a time. Classified as an unsaturated carboxylic acid, it occurs naturally in a number of plants. Articles of Cinnamic acid are included as well. LD The alkali salts are sol in water. Liu L, et al. Chemical Database Cinnamic Acid Identifications. Combustible. Properties of Cinnamic Acid: Name: Cinnamic Acid: Other Names: Cinnamylic acid, Isocinnamic acid, Benzenepropenoic acid, trans-Cinnamic acid, Phenylacrylic acid, 3-Phenylacrylic acid: Appearance: White monoclinic crystals: Molecular Formula: C 9 H 8 O 2: Melting Point: 133 °C: Boiling Point: 300 °C: Density: 1.2475 g/cm 3: Molar Mass: 148.161 g.mol –1: Solubility in Water 3.3). Cinnamic acid, ethanol and temperature interaction on coumarate decarboxylase activity and the relative expression of the putative cd gene in D. bruxellensis Growth rates are determined by cell counting. Environmental, Chemistry & Hazardous Materials News, Careers & Resources. ChemSynthesis Chemical database. Acide cinnamique Cinnamic acid for synthesis. PubChem Substance ID … Molecular Weight 148.16 . Mise à jour : 1984-01-30. Get all suppliers and price by the below link: Reference only. Propriétés physiques . Cinnamic acids play key roles in the formation of other more complex phenolic compounds. Identification Product Name trans-Cinnamic acid Cat No. You can also browse global suppliers,vendor,prices,Price,manufacturers of trans-Cinnamic acid(140-10-3). The alkali salts are sol in water. About Us | Mise à jour : 1984-01-30. Articles of Cinnamic acid are included as well. Molecular Weight: 153.19 g/mol. (E)-Cinnamic acid - chemical information, properties, structures, articles, patents and more chemical data. It serves as a precursor to the sweetener aspartame through enzyme-catalyzed amination to phenylalanine. It serves as a precursor to the sweetener aspartame through enzyme-catalyzed amination to phenylalanine. - Find MSDS or SDS, a COA, data sheets and more information. Cells are grown for 3 days at 37°C in the presence or absence of the drug, then detached with trypsin/EDTA and counted in a Coulter counter. MSDS/SDS Database Search | Molecular Formula: C 9 H 8 O 2; Molecular Weight: 148.161 g/mol; Cas Number: 140-10-3 ; EINECS Number: 205-398-1; MDL Number: MFCD00004369 ; InChIKey: WBYWAXJHAXSJNI … Cinnamic acid - cas 140-10-3, synthesis, structure, density, melting point, boiling point. Biologically Active Compounds | SAFETY DATA SHEET Creation Date 26-Sep-2009 Revision Date 14-Feb-2020 Revision Number 2 1. Cinnamic acid: a natural product with potential use in cancer intervention. Linear Formula C 6 H 5 CH=CHCOOH . Skip to page content; Skip to site menu on this page. Il a été découvert et purifié par Péligot et Dumas en 1834. Date s: Modify: 2020-10-10. Mise à jour : 1986-11-10. CAS Number : 621-82-9 : Molecular Formula : C9H8O2 : Molecular weight : 148.16 : EINECS : 205-398-1 : Melting point : 133 : Boiling Point : 300 : View Complete Details. Chemsrc provides Cinnamic acid(CAS#:621-82-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. It is a self-inhibitor produced by fungal spores to prevent germination. EC Number 205-398-1. Contact Seller Ask for best deal. Visit ChemicalBook To find more trans-Cinnamic acid(140-10-3) information like chemical properties,Structure,melting point,boiling point,density,molecular formula,molecular weight, physical properties,toxicity information,customs codes. Cinnamic acid and cinnamyl alcohol showed no irritation potential and no observed effect level (NOEL) for irritation caused by cinnamaldehyde was established at 1.25%. It is a white crystalline compound that is slightly soluble in water, and freely soluble in many organic solvents. Cinnamic acid: a natural product with potential use in cancer intervention. Cinnamic acid CAS 140-10-3. 1995 Jul 28;62(3):345-50. Beilstein/REAXYS Number 1905952 . Within 5 days of treatment with 5 mM Cinnamic acid, melanoma 1011 cells appear enlarged with a markedly increased cytoplasm-to-nuclear ratio and well organized cytoskeleton, developed long dendritic processes and became highly melanotic. It exists as both a cis and a trans isomer, although the latter is more common. CAS Number: 621-82-9; FEMA Number: 2288; Synonyms/Related: (2E)-3-phenylprop … NOEL for sensitization was determined at 2.5% and 0.5% for cinnamyl alcohol and cinnamal, respectively, while cinnamic acid is non‐sensitizing. Solide cristallin, jaunâtre à odeur aromatique. Liu L, et al. trans-Cinnamic acid ≥99% Synonym: trans-3-Phenylacrylic acid, Cinnamic acid CAS Number 140-10-3. cis-cinnamic acid: ChEBI ID CHEBI:35699: ChEBI ASCII Name cis-cinnamic acid: Definition The Z (cis) isomer of cinnamic acid: Stars This entity has been manually annotated by the ChEBI Team. B. Cinnamic acid is a monocarboxylic acid that consists of acrylic acid bearing a phenyl substituent at the 3-position. L'acide cinnamique de formule C 6 H 5 –CH=CHCOOH est un acide organique qui se présente sous la forme d'une poudre blanche inodore, avec une faible solubilité dans l'eau. Product Classification | Cinnamic acid (C 9 H 10 O 2-purity 99%) was obtained from Acros Organics (Thermo Fisher Scientific, NJ, USA), diluted in RPMI 1640 medium containing 0.1 g/L of L-glutamine, 2.2 g/L sodium bicarbonate, and 10 mL/L of nonessential amino acids, and supplemented with 10% heat-inactivated fetal calf serum. Mise à jour : 1986-11-10. Int J Cancer. serum. check more Cinnamic acid price, Home | It is a member of styrenes and a member of cinnamic acids. After 3 days of continuous treatment with Cinnamic acid, a dose-dependent loss of invasive capacity in 3 tested tumor lines is observed. It is found in Cinnamomum cassia. Display Name: trans-cinnamic acid EC Number: 205-398-1 EC Name: trans-cinnamic acid CAS Number: 140-10-3 Molecular formula: C9H8O2 IUPAC Name: (2E)-3-phenylprop-2-enoic acid trans-Cinnamic acid; Noms anglais : trans-Cinnamic acid; Utilisation et sources d'émission. Classified as an unsaturated carboxylic acid, it occurs naturally in a number of plants. Journals | Freely sol in benzene, ether, acetone, glacial acetic acid, carbon disulfide, oils. trans-Cinnamic acid is an antimicrobial activity, with minimal inhibitory concentration (MIC) of 250 μg/mL against fish pathogen A. sobria, SY-AS1. Cinnamic acid (CA) and ferulic acid (FA) are naturally occurring phenolic acids claimed to exert beneficial effects against disorders related to oxidative stress, including cancer. Synonyms: TRANS-CINNAMIC-D5 ACID. It exists as both a cis and a trans isomer, although the latter is more common. The change in the capacity of Cinnamic acid -treated melanoma 1011, A375(M) and SKMEL28 cells to degrade and cross tissue barriers is assessed by an in vitro invasion assay using modified Boyden chambers with matrigel-coated filters. IndiaMART > Industrial Chemicals & Supplies > Cinnamic Acid. Fabrication de produits organiques Hygiène et sécurité Apparence . Phenylacrylic acid; 3-Phenylacrylic acid; 3-Phenyl-2-propenoic acid, 2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%, 4-09-00-02002 (Beilstein Handbook Reference). Molecular Formula C 9 H 8 O 2; Average mass 148.159 Da; Monoisotopic mass 148.052429 Da; ChemSpider ID 392447 Get Latest Price Request a quote. Stable. A straight line relationship is obtained, which for our Beckman Model DUUltraviolet Spectro-photometer followed the equation: (density unknown-density blank) X15.8=mg. Int J Cancer. Buying Leads | The most plant phenolics are derived from trans-cinnamic acid, which is formed from l-phenylalanine by the action of l-phenylalanine ammonia-lyase (PAL), the branch point enzyme between primary (shikimate pathway) and secondary (phenyl propanoid pathway) metabolism (Fig. It is a self-inhibitor produced by fungal spores to prevent germination. A. It is also showed that 20 mM Cinnamic acid is needed to cause an IC50 in FS4 cells, i.e. : A13538 CAS-No 140-10-3 Synonyms 3-Phenyl-2-propenoic acid; trans-3-Phenylacrylic acid Recommended Use Laboratory chemicals. Cinnamic acid; 2-Propenoic acid, 3-phenyl- (E)-; trans-3-Phenylacrylic acid; trans-beta-Carboxystyrene Chemical Name: trans-Cinnamic Acid Chemical Formula: C9-H8-O2 Contact Information: Sciencelab.com, Inc. 14025 Smith Rd. Hazard Symbols: Xi - Irritant: Risk Codes: R36/37/38 - Irritating to eyes, respiratory system and skin. Service | Cinnamic acid. Enterprises. CINNAMIC ACID U14A832J8D Overview Structure Names 25: Classification 2: Identifiers 12: Relationships 4: Metabolites 1: Active Moiety 1: Notes 3: Audit Info References 34: History 1: … It is a white crystalline compound that is slightly soluble in water, and freely soluble in many organic solvents. Chemsrc provides Cinnamic acid(CAS#:621-82-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Cinnamic acid. EnvironmentalChemistry.com. cinnamic acid. Selling Leads | CAS 140-10-3, chemical formula C₆H₅CH=CHCOOH. LD 50 (g/kg): 3.57 orally in … This factor (15.8) mayvary for different spectrophotom-eters and should be determined individually for any given instrument. Details of the supplier of the safety data … trans-Cinnamic acid is used in flavors, synthetic indigo and pharmaceuticals. Shanghai Jizhi Biochemical Technology Co., Ltd. Cinnamic acid has potential use in cancer intervention, with IC50s of 1-4.5 mM in glioblastoma, melanoma, prostate and lung carcinoma cells. ethyl 4-imino-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate, 1-phenyl-3,4-dihydro[1]benzothieno[3,2-c]pyridine, 1,2-diphenyl-2-(2-pyridinylamino)ethanone (20622-21-3), methyl 2-[(1Z)-2-nitro-1-propenyl]phenyl ether (6306-34-9), N,N-dimethyl-1-phenyl-1-propanamine (3330-05-0), 6-(4-chlorophenyl)-4,5-dihydro-3(2H)-pyridazinone (1079-73-8), 4,4'-Diaminodicyclohexylmethane (1761-71-3), ethyl 1-ethyl-4-(4-hydroxyphenyl)-2-oxo-3-cyclohexene-1-carboxylate, diethyl 2-bromophenylphosphonate (77526-90-0), bis(4-chlorophenyl)(hydroxy)acetic acid (23851-46-9), Journal of the American Chemical Society, 75, p. 1068, 1953. Propriétés physiques . Rs 850/ Kilogram Get Latest Price. Treatment with 5 mM Cinnamic acid results in 75-95% loss of invasiveness[1]. Viability is determined by Trypan-blue exclusion assay[1]. Houston, Texas 77396 US Sales: 1-800-901-7247 International Sales: 1-281-441-4400 Order Online: ScienceLab.com CHEMTREC (24HR Emergency … This page contains information on the chemical Cinnamic Acid including: 56 synonyms/identifiers. At last,trans-Cinnamic acid… 1995 Jul 28;62(3):345-50. cinnamic acid, (E)-Formula: C 9 H 8 O 2: Molar Mass: 148.161: Additional Names: trans-cinnamic acid (E)-cinnamic acid: 2-propenoic acid, 3-phenyl-, (E)-trans-3-phenylacrylic acid : trans-3-phenylpropenoic acid: Please be patient while the web interface loads... Property Availability . Uses advised against Food, drug, pesticide or biocidal product use. [1]. Incompatible with strong oxidizing agents. trans-cinnamic acid shows moderate inhibition on the rainbow trout intestinal isolates A. sobria SY-AS3 and S. baltica, SY-S145, gill isolate F. spartansii SY-FS1 and fish pathogens A. salmonicida ATCC 33658, Listonella anguillarum, SY-L24, V. crassostreae SY … Briefly, 5 X104 cells are plated in each well of a 24-well plate, allowed to attach overnight, and treated with compounds (e.g., Cinnamic acid: 2.5, 5, 10, 20, 30 mM) the following day. Customer Support; Technical Service; … trans-Cinnamic acid is used in flavors, synthetic indigo and pharmaceuticals. Home; Text Search; Structure Search ; About; GO. 5 to 20 times more than for tumor cells. Density: 1.185g/cm 3: Melting Point: 131-136℃ Boling Point: 264.999°C at 760 mmHg: Flash Point: 189.53°C: Solubility: 0.4 g/L (20℃) Vapor Presure: 0.005mmHg at 25°C: Refractive Index: 1.616: trans-Cinnamic acid - Risk and Safety. Cinnamic acid is an organic compound with the formula C6H5CH=CHCOOH. cinnamic acid per 100 ml. The cell lines used, established from human malignant tumors, are A549 (lung cancer); PC3(M), Du145, and LNCaP (prostate cancer); A172, U251 (glioblastoma); and SKMEL28, A375(M), 1011 (melanoma). It is involved in the production of methyl, ethyl and benzyl esters, which is used in the perfume industry. In addition to inhibiting tumor-cell proliferation, Cinnamic acid causes morphological changes consistent with melanocyte differentiation. MDL number MFCD00004369. Cinnamic acid is an organic compound with the formula C6H5CH=CHCOOH. It has a role as a plant metabolite. Create: Disclaimer, Copyright © 2018 ChemSrc All Rights Reserved. Treatment with Cinnamic acid (CINN) of various tumor cells of epithelial and neuroectodermal origin result in dose-dependent growth inhibition following a 3-day exposure. 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